Review
doi: 10.1016/j.smim.2005.05.001.
Heterogeneity of thymic dendritic cells
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- PMID: 15946853
- DOI: 10.1016/j.smim.2005.05.001
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Review
Heterogeneity of thymic dendritic cells
Semin Immunol.
2005 Aug.
Abstract
Thymus is the site of generation and selection of T-lymphocytes. It also contains phenotypically and functionally distinct dendritic cell (DC) populations, including conventional DC (cDC) and plasmacytoid DC (pDC). Thymic cDC are heterogeneous and contain two subsets: a major subset derived from the precursors within thymus, and a minor subset presumably of extrathymic origin. Increasing evidence suggest that thymic cDC can cross-present self-antigens to developing thymocytes and play an important role in thymocyte negative selection and central tolerance induction. Thymic pDC can produce type-I interferon upon appropriate activation. However, their role in a steady state thymus is currently unclear.
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