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Review
. 2005 May;10(2):299-310.
doi: 10.1517/14728214.10.2.299.

Targeting cellular adhesion molecules, chemokines and chemokine receptors in rheumatoid arthritis

Jasper J Haringman  1 , Roos L Oostendorp, Paul P Tak
Affiliations
Review

Targeting cellular adhesion molecules, chemokines and chemokine receptors in rheumatoid arthritis

Jasper J Haringman et al. Expert Opin Emerg Drugs. 2005 May.

Abstract

The development of specific targeted therapies, such as anti-TNF-alpha treatment, for chronic inflammatory disorders such as rheumatoid arthritis, has significantly improved treatment, although not all patients respond. Targeting cellular adhesion molecules and chemokines/chemokine receptors as regulators of the extravasation and migration of leukocytes may provide a novel approach for the treatment of these diseases. Moreover, the possibility of developing small-molecule antagonists offers an excellent method for the oral delivery of compounds with a short half-life.

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