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. 2005 Jun;21(6):322-6.
doi: 10.1016/j.tig.2005.04.008.

Mammalian microRNAs derived from genomic repeats

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Mammalian microRNAs derived from genomic repeats

Neil R Smalheiser et al. Trends Genet. 2005 Jun.

Abstract

In this article, we show that a subset of conventional mammalian microRNAs is derived from LINE-2 transposable elements and other genome repeats. These repeat-derived microRNAs arise from conventional precursor hairpins and are distinct from the rasiRNAs, which appear to be processed from long double-stranded RNA precursors. The insertion of transposable elements into new genomic sites appears to be one of the driving-forces that create new microRNAs during mammalian evolution. Two of the LINE-2-derived microRNAs exhibit perfect complementarity to a large family of mRNA and EST transcripts that contain portions of MIR and other LINE-2 elements in their 3'-untranslated regions.

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