Dopaminergic activation of estrogen receptors in neonatal brain alters progestin receptor expression and juvenile social play behavior
- PMID: 15919740
- DOI: 10.1210/en.2005-0498
Dopaminergic activation of estrogen receptors in neonatal brain alters progestin receptor expression and juvenile social play behavior
Abstract
Steroid receptor activation in developing brain influences a variety of cellular processes that endure into adulthood, altering both behavior and physiology. We report that estrogen receptors can be activated in a ligand-independent manner within developing brain by membrane dopamine receptors. Neonatal treatment with either estradiol or a dopamine D1 receptor agonist can increase the expression of an estrogen receptor-regulated gene (i.e. progestin receptors) and later juvenile social play. More importantly, increases in social play behavior induced by neonatal treatment with estradiol or a dopamine D1 receptor agonist can be prevented by prior treatment with an estrogen receptor antagonist. This suggests that changes in dopamine transmission in developing brain can activate estrogen receptors in a ligand-independent manner to influence gene expression and have lasting consequences on social behavior.
Comment in
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Possible contribution of neonatal ligand-independent activation of estradiol receptors to male-typical sexual differentiation of brain and behavior.Endocrinology. 2005 Sep;146(9):3702-4. doi: 10.1210/en.2005-0656. Endocrinology. 2005. PMID: 16105829 Review. No abstract available.
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