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Review
. 2005 Jun;17(3):262-8.
doi: 10.1016/j.ceb.2005.04.014.

Promoter usage and alternative splicing

Alberto R Kornblihtt  1
Affiliations
Review

Promoter usage and alternative splicing

Alberto R Kornblihtt. Curr Opin Cell Biol. 2005 Jun.

Abstract

Recent findings justify a renewed interest in alternative splicing (AS): the process is more a rule than an exception as it affects the expression of 60% of human genes; it explains how a vast mammalian proteomic complexity is achieved with a limited number of genes; and mutations in AS regulatory sequences are a widespread source of human disease. AS regulation not only depends on the interaction of splicing factors with their target sequences in the pre-mRNA but is coupled to transcription. A clearer picture is emerging of the mechanisms by which transcription affects AS through promoter identity and occupation. These mechanisms involve the recruitment of factors with dual functions in transcription and splicing (i.e. that contain both functional domains and hence link the two processes) and the control of RNA polymerase II elongation.

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