doi: 10.1021/bc050047f.
The peptide route to multifunctional gold nanoparticles
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- PMID: 15898714
- DOI: 10.1021/bc050047f
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The peptide route to multifunctional gold nanoparticles
Bioconjug Chem.
2005 May-Jun.
Abstract
Extremely stable, peptide-capped gold nanoparticles with two different biomolecular recognition motifs expressed on their surface have been prepared, and their specific and selective binding to artificial, DNA-modified target particles and to DNA and protein microarrays has been demonstrated. Stabilization and biofunctionalization has been achieved in a single preparative step starting with citrate-stabilized gold hydrosols and a derivatization cocktail of peptide-capping ligands, which carry the functionalities of choice.
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