Review
doi: 10.1002/jcp.20356.
Disruption of protein-protein interactions: towards new targets for chemotherapy
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- PMID: 15880642
- DOI: 10.1002/jcp.20356
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Review
Disruption of protein-protein interactions: towards new targets for chemotherapy
J Cell Physiol.
2005 Sep.
Abstract
Protein-protein interactions play a key role in various mechanisms of cellular growth and differentiation, and in the replication of pathogen organisms in host cells. Thus, inhibition of these interactions is a promising novel approach for rational drug design against a wide number of cellular and microbial targets. In the past few years, attempts to inhibit protein-protein interactions using antibodies, peptides, and synthetic or natural small molecules have met with varying degrees of success, and these will be the focus of this review.
Copyright 2005 Wiley-Liss, Inc.
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