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. 2005 Jun;6(6):626-34.
doi: 10.1038/ni1203. Epub 2005 May 8.

Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1

Fabio M V Rossi  1 , Stephane Y Corbel, Jasmeen S Merzaban, Douglas A Carlow, Klaus Gossens, Jeffrey Duenas, Leslie So, Lin Yi, Hermann J Ziltener
Affiliations

Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1

Fabio M V Rossi et al. Nat Immunol. 2005 Jun.

Abstract

The molecular mechanisms that direct the migration of early T lymphocyte progenitors to the thymus are unknown. We show here that P-selectin is expressed by thymic endothelium and that lymphoid progenitors in bone marrow and thymus bind P-selectin. Parabiosis, competitive thymus reconstitution and short-term homing assays indicated that P-selectin and its ligand PSGL-1 are functionally important components of the thymic homing process. Accordingly, thymi of mice lacking PSGL-1 contained fewer early thymic progenitors and had increased empty niches for prothymocytes compared with wild-type mice. Furthermore, the number of resident thymic progenitors controls thymic expression of P-selectin, suggesting that regulation of P-selectin expression by a thymic 'niche occupancy sensor' may be used to direct progenitor access.

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