Review
doi: 10.1016/j.cub.2005.04.004.
Actin nucleation: spire - actin nucleator in a class of its own
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- PMID: 15854898
- DOI: 10.1016/j.cub.2005.04.004
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Review
Actin nucleation: spire - actin nucleator in a class of its own
Curr Biol.
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Free article
Abstract
The rate limiting step for actin filament polymerisation is nucleation, and two types of nucleator have been described: the Arp2/3 complex and the formins. A recent study has now identified in Spire a third class of actin nucleator. The four short WH2 repeats within Spire bind four consecutive actin monomers to form a novel single strand nucleus for 'barbed end' actin filament elongation.
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