doi: 10.1016/j.chembiol.2005.02.004.
Switching between allosteric and dimerization inhibition of HIV-1 protease
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- PMID: 15850980
- DOI: 10.1016/j.chembiol.2005.02.004
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Switching between allosteric and dimerization inhibition of HIV-1 protease
Chem Biol.
2005 Apr.
Abstract
Refining the functional groups on a phenethylamine moiety within an inhibitor of HIV-1 protease led to a switch in the mechanism of inhibition from competitive and allosteric to dimerization inhibition. Phenylether extensions to the phenethylamine group led to agents that target the dimerization interface of HIV-1 protease with high potency.
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