Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Jun;126(1-2):171-7.
doi: 10.1016/j.jviromet.2005.02.005.

Study on the resistance of severe acute respiratory syndrome-associated coronavirus

Xin-Wei Wang  1 , Jin-Song Li, Min Jin, Bei Zhen, Qing-Xin Kong, Nong Song, Wen-Jun Xiao, Jing Yin, Wei Wei, Gui-Jie Wang, Bing-Yin Si, Bao-Zhong Guo, Chao Liu, Guo-Rong Ou, Min-Nian Wang, Tong-Yu Fang, Fu-Huan Chao, Jun-Wen Li
Affiliations

Study on the resistance of severe acute respiratory syndrome-associated coronavirus

Xin-Wei Wang et al. J Virol Methods. 2005 Jun.

Abstract

In this study, the persistence of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) was observed in feces, urine and water. In addition, the inactivation of SARS-CoV in wastewater with sodium hypochlorite and chlorine dioxide was also studied. In vitro experiments demonstrated that the virus could only persist for 2 days in hospital wastewater, domestic sewage and dechlorinated tap water, while 3 days in feces, 14 days in PBS and 17 days in urine at 20 degrees C. However, at 4 degrees C, the SARS-CoV could persist for 14 days in wastewater and at least 17 days in feces or urine. SARS-CoV is more susceptible to disinfectants than Escherichia coli and f2 phage. Free chlorine was found to inactivate SARS-CoV better than chlorine dioxide. Free residue chlorine over 0.5 mg/L for chlorine or 2.19 mg/L for chlorine dioxide in wastewater ensures complete inactivation of SARS-CoV while it does not inactivate completely E. coli and f2 phage.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Detection of SARS-CoV RNA from the seeded samples for 7 days. (1) Negative control; (2) cell control; (3) positive control (348 bp); (4) marker (pUC19 DNA/MSP I Marker); (5) wastewater of the 309th hospital; (6) normal saline; (7) municipal sewage; (8) dechlorinated water.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. American Public Health Association (APHA) twentieth ed. American Public Health Association; Washington, DC: 1980. Standard Methods For The Examination Of Water And Wastewater.
    1. Bao Z., Liu Y., Liu S., Zhuang D., Li J. Endurance of SARS virus to different temperatures. Chin. J. Disinfection [in Chinese] 2003;20:161–162.
    1. Cyranoski, D., Abbott, A., 2003. Apartment complex holds clues to pandemic potential of SARS. Nature. 423:1038/423003a. - PMC - PubMed
    1. Duan S.M., Zhao X.S., Wen R.F., Huang J.J., Pi G.H., Zhang S.X., Han J., Bi S.L., Ruan L., Dong X.P., SARS Research Team Stability of SARS coronavirus in human specimens and environment and its sensitivity to heating and UV irradiation. Biomed. Environ. Sci. 2003;16:246–255. - PubMed
    1. Enserink M. The big question now: will it be back? Science. 2004;301:299. - PubMed

Publication types

MeSH terms

LinkOut - more resources