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. 2005 Jun;35(6):601-7.
doi: 10.1007/s00247-005-1413-y. Epub 2005 Mar 23.

Obesity and fat quantification in lean tissues using three-point Dixon MR imaging

Arzu Kovanlikaya  1 , Steven D Mittelman, Andrette Ward, Mitchell E Geffner, Frederick Dorey, Vicente Gilsanz
Affiliations

Obesity and fat quantification in lean tissues using three-point Dixon MR imaging

Arzu Kovanlikaya et al. Pediatr Radiol. 2005 Jun.

Abstract

Background: It has been suggested that increased hepatic and intramuscular fat is associated with insulin resistance, and that increased pancreatic fat is related to impaired insulin secretion.

Objective: We postulated that in obese nondiabetic teenagers insulin levels would be directly related to increases in intramuscular and hepatic fat and inversely related to increases in pancreatic fat.

Materials and methods: MRI was used to assess the percentage of fat in the liver, muscle and pancreas in 15 healthy Mexican-American girls, 14-17 years old, with body mass indexes (BMIs) ranging from 17.7 kg/m(2) to 46 kg/m(2).

Results: Strong correlations were observed between BMI and fat content in the liver, muscle, and pancreas (r(2)s between 0.50 and 0.89; P<0.003). Serum insulin levels were closely associated with fat measures in the muscle and liver (r(2s)=0.63 and 0.29, and P=0.001 and P=0.023, respectively). In contrast to our hypothesis, fat content in the pancreas was also directly related to insulin secretion (r(2)=0.74; P=0.001).

Summary: We conclude that in nondiabetic teenagers, obesity is associated with an increased accumulation of fat in the pancreas without impairment of insulin secretion.

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