Skip to main page content
U.S. flag

An official website of the United States government

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Apr 15;329(3):976-83.
doi: 10.1016/j.bbrc.2005.02.062.

PDGF-D contributes to neointimal hyperplasia in rat model of vessel injury

Jingzhou Chen  1 , Yu Han, Chunxia Lin, Yisong Zhen, Xiaodong Song, Siyong Teng, Chen Chen, Yu Chen, Yinhui Zhang, Rutai Hui
Affiliations

PDGF-D contributes to neointimal hyperplasia in rat model of vessel injury

Jingzhou Chen et al. Biochem Biophys Res Commun. .

Abstract

In this study, we determined the role of PDGF-D, a new member of the PDGF family, in a rat model of balloon injured artery made with a 2F catheter in Sprague-Dawley male rats. PDGF-D expression was studied in the injured and control segments of abdominal aorta. The function of PDGF-D was evaluated in rat vascular smooth muscle cells stably transfected with PDGF-D gene. We found that in normal abdominal aorta, PDGF-D was highly expressed in adventia, moderate in endothelia, and unidentified in media. Stable transfection of PDGF-D gene into vascular smooth muscle cells increased the cell migration by 2.2-fold, and the proliferation by 2.3-fold, respectively, and MMP-2 production and activity as well. These results support the fact that PDGF-D is involved in the formation of neointimal hyperplasia induced by balloon catheter injury and may serve as a target in preventing vascular restenosis after coronary angioplasty.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources