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Comparative Study
. 2005 Apr 1;209(1):39-45.
doi: 10.1016/j.tox.2004.12.003. Epub 2005 Jan 8.

Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin

Yusuf Kalender  1 , Mustafa Yel, Suna Kalender
Affiliations
Comparative Study

Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin

Yusuf Kalender et al. Toxicology. .

Abstract

Doxorubicin (DXR) is an anthracycline antibiotic, broadly used in tumor therapy. In the present study we investigated whether vitamin E and catechin can reduce the toxic effects of doxorubicin. Vitamin E (200 IU/kg/week), catechin (200 mg/kg/week), doxorubicin (5 mg/kg/week), doxorubicin+vitamin E (200 IU/kg/week), doxorubicin+catechin (200 mg/kg/week) combinations were given to rats weighing 210-230 g (n=6/group). Changes in major enzymes participating in free radical metabolism superoxide dismutase (Cu,Zn-SOD), glutathione peroxidase (GSHPx), catalase (CAT) and malondialdehyde (MDA) were evaluated in the livers of all animals. Superoxide dismutase and catalase activity increased in the doxorubicin-treated group compared to control (P<0.05). Glutathione peroxidase levels increased in the catechin+doxorubicin-treated group (P<0.05) and reached maximum concentrations in the doxorubicin-treated group compared to control (P<0.01). Malondialdehyde levels increased in the doxorubicin-treated group compared to control and all-treated groups (P<0.05). Malondialdehyde, glutathione peroxidase and catalase activities were decreased in the vitamin E+doxorubicin- and catechin+doxorubicin-treated group compared to doxorubicin-treated group (P<0.05). All enzymes activities showed no statistical differences in the not mentioned groups above (P>0.05). Electron microscopic studies supported biochemical findings. We conclude that vitamin E and catechin significantly reduce doxorubicin-induced hepatotoxicity in rats.

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