Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Apr;36(1):90-6.

Quantitative assessment of the effects of platelet depletion in the autologous phase of nephrotoxic serum nephritis

M Sindrey, T L Marshall, P Naish

Quantitative assessment of the effects of platelet depletion in the autologous phase of nephrotoxic serum nephritis

M Sindrey et al. Clin Exp Immunol. 1979 Apr.

Abstract

The effects of platelet depletion with antibody have been studied in two models of the autologous phase of nephrotoxic nephritis in the rabbit. In the 'telescoped' model (animals pre-immunized to sheep IgG injected with sheep nephrotoxic antibody), platelet depletion did not alter intraglomerular fibrin deposition or evidence of glomerular damage, but did significantly reduce proteinuria during the first 3 days of the 5 day experiment. In the 'passive' model (animals injected with hyperimmune rabbit antiserum to sheep IgG 48 hr after sheep nephrotoxic antibody and killed 3 hr later), platelet depletion was associated with significantly fewer intraglomerular polymorphonuclear leucocytes (PMN), but again did not alter intraglomerular fibrin deposition. The results indicate that platelets are involved in the initiation of glomerular PMN localization in the autologous phase, but that fibrin-induced glomerular injury is platelet-independent.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Lab Clin Med. 1976 Jun;87(6):967-75 - PubMed
    1. J Exp Med. 1978 Feb 1;147(2):369-84 - PubMed
    1. Int Arch Allergy Appl Immunol. 1966;29(2):185-9 - PubMed
    1. Clin Sci. 1972 May;42(5):643-6 - PubMed
    1. Clin Exp Immunol. 1979 Mar;35(3):350-5 - PubMed

LinkOut - more resources