Intracellular targeting of polymer-bound drugs for cancer chemotherapy
- PMID: 15722167
- DOI: 10.1016/j.addr.2004.10.006
Intracellular targeting of polymer-bound drugs for cancer chemotherapy
Abstract
Macromolecules have been traditionally employed as drug carriers due to their ability to selectively accumulate in malignant tissues compared to healthy tissues by either passive or active targeting, thus precluding undesirable side effects generated by free drug. The therapeutic activity proffered by such conjugates requires that the drug concentrate at its specific subcellular target such as the nucleus. Thus, the suitability of macromolecules as carriers also extends to their propensity to deliver the drug to a predetermined intracellular location. As binding a macromolecule to a drug facilitates cellular uptake by endocytosis, various approaches have been employed to either guide the drug to targets different from endosomal/lysosomal compartments by mediating vesicular escape, or to directly accomplish intracellular (cytoplasmic and nuclear) localization. This review discusses the utility of macromolecules in drug delivery and describes the numerous modalities (with a focus on cell-penetrating peptides) currently available for achieving effective intracellular drug delivery.
Similar articles
-
Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells.Bioconjug Chem. 2003 Jan-Feb;14(1):44-50. doi: 10.1021/bc0255900. Bioconjug Chem. 2003. PMID: 12526691
-
A TAT-streptavidin fusion protein directs uptake of biotinylated cargo into mammalian cells.Protein Eng Des Sel. 2005 Mar;18(3):147-52. doi: 10.1093/protein/gzi014. Epub 2005 Apr 8. Protein Eng Des Sel. 2005. PMID: 15820981
-
Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer.Adv Drug Deliv Rev. 2005 Feb 28;57(4):579-96. doi: 10.1016/j.addr.2004.10.005. Epub 2004 Dec 19. Adv Drug Deliv Rev. 2005. PMID: 15722165 Review.
-
Subcellular trafficking of HPMA copolymer-Tat conjugates in human ovarian carcinoma cells.J Control Release. 2003 Aug 28;91(1-2):53-9. doi: 10.1016/s0168-3659(03)00213-x. J Control Release. 2003. PMID: 12932637
-
Nuclear delivery of macromolecules: barriers and carriers.Adv Drug Deliv Rev. 2005 Feb 28;57(4):505-27. doi: 10.1016/j.addr.2004.10.004. Epub 2004 Dec 28. Adv Drug Deliv Rev. 2005. PMID: 15722161 Review.
Cited by
-
Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates.Macromolecules. 2012 Mar 13;45(5):2225-2232. doi: 10.1021/ma202581d. Epub 2012 Feb 27. Macromolecules. 2012. PMID: 23357880 Free PMC article.
-
Nanomedicinal strategies to treat multidrug-resistant tumors: current progress.Nanomedicine (Lond). 2010 Jun;5(4):597-615. doi: 10.2217/nnm.10.35. Nanomedicine (Lond). 2010. PMID: 20528455 Free PMC article. Review.
-
Drug Delivery Systems Obtained from Silica Based Organic-Inorganic Hybrids.Polymers (Basel). 2016 Mar 24;8(4):91. doi: 10.3390/polym8040091. Polymers (Basel). 2016. PMID: 30979199 Free PMC article. Review.
-
Polymer-drug conjugates: origins, progress to date and future directions.Adv Drug Deliv Rev. 2013 Jan;65(1):49-59. doi: 10.1016/j.addr.2012.10.014. Epub 2012 Nov 2. Adv Drug Deliv Rev. 2013. PMID: 23123294 Free PMC article. Review.
-
Nanovehicular intracellular delivery systems.J Pharm Sci. 2008 Sep;97(9):3518-90. doi: 10.1002/jps.21270. J Pharm Sci. 2008. PMID: 18200527 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
