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Comparative Study
. 2005 Feb;73(1):78-85.
doi: 10.1037/0022-006X.73.1.78.

Two-year prospective naturalistic study of remission from major depressive disorder as a function of personality disorder comorbidity

Carlos M Grilo  1 , Charles A Sanislow, M Tracie Shea, Andrew E Skodol, Robert L Stout, John G Gunderson, Shirley Yen, Donna S Bender, Maria E Pagano, Mary C Zanarini, Leslie C Morey, Thomas H McGlashan
Affiliations
Comparative Study

Two-year prospective naturalistic study of remission from major depressive disorder as a function of personality disorder comorbidity

Carlos M Grilo et al. J Consult Clin Psychol. 2005 Feb.

Abstract

In this study, the authors examined prospectively the 24-month natural course of remission from major depressive disorder (MDD) as a function of personality disorder (PD) comorbidity. In 302 participants (196 women, 106 men), psychiatric and PDs were assessed at baseline with diagnostic interviews, and the course of MDD was assessed with the Longitudinal Interval Follow-Up Evaluation at 6-, 12-, and 24-month follow-ups. Survival analyses revealed an overall 24-month remission rate of 73.5% for MDD that differed little by gender. Participants with MDD who had certain forms of coexisting PD psychopathology (schizotypal, borderline, or avoidant) as their primary PD diagnoses had a significantly longer time to remission from MDD than did patients with MDD without any PD. These PDs emerged as robust predictors of slowed remission from MDD even when controlling for other negative prognostic predictors.

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Figures

Figure 1
Figure 1
Survival curves (time to remission) for major depressive disorder (MDD) as a function of personality disorder comorbidity. STPD = schizotypal personality disorder; BPD = borderline personality disorder; AVPD = avoidant personality disorder; OCPD = obsessive-compulsive personality disorder.
Figure 2
Figure 2
Survival curves for major depressive disorder (MDD) across the five study groups, separately for men (A) and women (B). STPD = schizotypal personality disorder; BPD = borderline personality disorder; AVPD = avoidant personality disorder; OCPD = obsessive-compulsive personality disorder.
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