Intraglomerular inhibition: signaling mechanisms of an olfactory microcircuit
- PMID: 15696160
- DOI: 10.1038/nn1403
Intraglomerular inhibition: signaling mechanisms of an olfactory microcircuit
Abstract
Microcircuits composed of principal neuron and interneuron dendrites have an important role in shaping the representation of sensory information in the olfactory bulb. Here we establish the physiological features governing synaptic signaling in dendrodendritic microcircuits of olfactory bulb glomeruli. We show that dendritic gamma-aminobutyric acid (GABA) release from periglomerular neurons mediates inhibition of principal tufted cells, retrograde inhibition of sensory input and lateral signaling onto neighboring periglomerular cells. We find that L-type dendritic Ca(2+) spikes in periglomerular cells underlie dendrodendritic transmission by depolarizing periglomerular dendrites and activating P/Q type channels that trigger GABA release. Ca(2+) spikes in periglomerular cells are evoked by powerful excitatory inputs from a single principal cell, and glutamate release from the dendrites of single principal neurons activates a large ensemble of periglomerular cells.
Similar articles
-
Self-inhibition of olfactory bulb neurons.Nat Neurosci. 2002 Aug;5(8):760-6. doi: 10.1038/nn882. Nat Neurosci. 2002. PMID: 12089528
-
Presynaptic muscarinic receptors enhance glutamate release at the mitral/tufted to granule cell dendrodendritic synapse in the rat main olfactory bulb.J Neurophysiol. 2009 Apr;101(4):2052-61. doi: 10.1152/jn.90734.2008. Epub 2009 Feb 18. J Neurophysiol. 2009. PMID: 19225175
-
Dendritic sodium spikelets and low-threshold calcium spikes in turtle olfactory bulb granule cells.J Neurophysiol. 2005 Mar;93(3):1285-94. doi: 10.1152/jn.00807.2004. Epub 2004 Oct 13. J Neurophysiol. 2005. PMID: 15483062
-
synaptic organization of the glomerulus in the main olfactory bulb: compartments of the glomerulus and heterogeneity of the periglomerular cells.Anat Sci Int. 2005 Jun;80(2):80-90. doi: 10.1111/j.1447-073x.2005.00092.x. Anat Sci Int. 2005. PMID: 15960313 Review.
-
[Current concepts of general properties and plastic phenomena in hippocampal neurons].Usp Fiziol Nauk. 1984 Jan-Mar;15(1):28-54. Usp Fiziol Nauk. 1984. PMID: 6322465 Review. Russian. No abstract available.
Cited by
-
Encoding innately recognized odors via a generalized population code.Curr Biol. 2021 May 10;31(9):1813-1825.e4. doi: 10.1016/j.cub.2021.01.094. Epub 2021 Mar 1. Curr Biol. 2021. PMID: 33651991 Free PMC article.
-
Spatio-Temporal Characteristics of Inhibition Mapped by Optical Stimulation in Mouse Olfactory Bulb.Front Neural Circuits. 2016 Mar 22;10:15. doi: 10.3389/fncir.2016.00015. eCollection 2016. Front Neural Circuits. 2016. PMID: 27047340 Free PMC article.
-
Intraglomerular lateral inhibition promotes spike timing variability in principal neurons of the olfactory bulb.J Neurosci. 2015 Mar 11;35(10):4319-31. doi: 10.1523/JNEUROSCI.2181-14.2015. J Neurosci. 2015. PMID: 25762678 Free PMC article.
-
Metabotropic glutamate receptors and dendrodendritic synapses in the main olfactory bulb.Ann N Y Acad Sci. 2009 Jul;1170:224-38. doi: 10.1111/j.1749-6632.2009.03891.x. Ann N Y Acad Sci. 2009. PMID: 19686141 Free PMC article.
-
Activation of postsynaptic GABAB receptors modulates the bursting pattern and synaptic activity of olfactory bulb juxtaglomerular neurons.J Neurophysiol. 2008 Jan;99(1):308-19. doi: 10.1152/jn.01086.2007. Epub 2007 Nov 21. J Neurophysiol. 2008. PMID: 18032562 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous
