Review
doi: 10.1038/nrm1549.
Focal adhesion kinase: in command and control of cell motility
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- PMID: 15688067
- DOI: 10.1038/nrm1549
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Review
Focal adhesion kinase: in command and control of cell motility
Nat Rev Mol Cell Biol.
2005 Jan.
Abstract
A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.
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