Comparative Study
doi: 10.1016/0168-1702(92)90042-8.
Nucleotide sequence comparison of the M1 genome segment of reovirus type 1 Lang and type 3 Dearing
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- PMID: 1566600
- DOI: 10.1016/0168-1702(92)90042-8
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Comparative Study
Nucleotide sequence comparison of the M1 genome segment of reovirus type 1 Lang and type 3 Dearing
Virus Res.
1992 Feb.
Abstract
The mammalian reoviruses possess a genome composed of 10 double stranded RNA segments. The serotype 1 strain Lang M1 segment was sequenced and compared to the published type 3 sequence. Both segments were 2304 base-pairs long coding for the mu 2 protein predicted to be 736 amino acids long. The sequences were highly conserved with 97.2% conservation of nucleotide sequence and 98.6% conservation of amino acid sequence. The M1 segments of serotypes 1 and 3 have recently diverged as indicated by the distribution of variation with respect to codon positions. The conservation of amino acid sequence indicated that the mu 2 protein has a relatively high functional density.
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