Epigenetic mechanisms in memory formation
- PMID: 15654323
- DOI: 10.1038/nrn1604
Epigenetic mechanisms in memory formation
Abstract
Discoveries concerning the molecular mechanisms of cell differentiation and development have dictated the definition of a new sub-discipline of genetics known as epigenetics. Epigenetics refers to a set of self-perpetuating, post-translational modifications of DNA and nuclear proteins that produce lasting alterations in chromatin structure as a direct consequence, and lasting alterations in patterns of gene expression as an indirect consequence. The area of epigenetics is a burgeoning subfield of genetics in which there is considerable enthusiasm driving new discoveries. Neurobiologists have only recently begun to investigate the possible roles of epigenetic mechanisms in behaviour, physiology and neuropathology. Strikingly, the relevant data from the few extant neurobiology-related studies have already indicated a theme - epigenetic mechanisms probably have an important role in synaptic plasticity and memory formation.
Similar articles
-
Epigenetic regulation of genes in learning and memory.Essays Biochem. 2010 Sep 20;48(1):263-74. doi: 10.1042/bse0480263. Essays Biochem. 2010. PMID: 20822498 Review.
-
Epigenetic gene regulation in cancer.Adv Genet. 2008;61:247-67. doi: 10.1016/S0065-2660(07)00009-0. Adv Genet. 2008. PMID: 18282509 Review.
-
The prevalence of epigenetic mechanisms in the regulation of cognitive functions and behaviour.Curr Opin Neurobiol. 2010 Aug;20(4):441-9. doi: 10.1016/j.conb.2010.04.007. Epub 2010 May 6. Curr Opin Neurobiol. 2010. PMID: 20451368
-
[Epigenetic regulation in alcohol-related brain damage].Nihon Arukoru Yakubutsu Igakkai Zasshi. 2008 Oct;43(5):705-13. Nihon Arukoru Yakubutsu Igakkai Zasshi. 2008. PMID: 19068777 Review. Japanese.
-
Brain plasticity, memory and neurological disorders: an epigenetic perspective.Neuroreport. 2010 Oct 6;21(14):909-13. doi: 10.1097/WNR.0b013e32833e9288. Neuroreport. 2010. PMID: 20717061 Review.
Cited by
-
Adverse childhood experiences and burn pain: a review of biopsychosocial mechanisms that may influence healing.Pain Rep. 2022 Jun 6;7(4):e1013. doi: 10.1097/PR9.0000000000001013. eCollection 2022 Jul-Aug. Pain Rep. 2022. PMID: 38304399 Free PMC article. Review.
-
REM Sleep Loss-Induced Elevated Noradrenaline Plays a Significant Role in Neurodegeneration: Synthesis of Findings to Propose a Possible Mechanism of Action from Molecule to Patho-Physiological Changes.Brain Sci. 2023 Dec 21;14(1):8. doi: 10.3390/brainsci14010008. Brain Sci. 2023. PMID: 38275513 Free PMC article. Review.
-
The synergic effects of presynaptic calcium channel antagonists purified from spiders on memory elimination of glutamate-induced excitotoxicity in the rat hippocampus trisynaptic circuit.Front Mol Biosci. 2023 Nov 30;10:1243976. doi: 10.3389/fmolb.2023.1243976. eCollection 2023. Front Mol Biosci. 2023. PMID: 38099194 Free PMC article.
-
DNA Methylation Inhibition Reversibly Impairs the Long-Term Context Memory Maintenance in Helix.Int J Mol Sci. 2023 Sep 14;24(18):14068. doi: 10.3390/ijms241814068. Int J Mol Sci. 2023. PMID: 37762369 Free PMC article.
-
Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential.Signal Transduct Target Ther. 2023 Aug 30;8(1):309. doi: 10.1038/s41392-023-01519-z. Signal Transduct Target Ther. 2023. PMID: 37644009 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical