Review
doi: 10.1038/nrm1568.
Assembly and function of RNA silencing complexes
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- PMID: 15654322
- DOI: 10.1038/nrm1568
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Review
Assembly and function of RNA silencing complexes
Nat Rev Mol Cell Biol.
2005 Feb.
Abstract
In the RNA-interference pathway, double-stranded RNA induces sequence-specific mRNA degradation through the action of the RNA-induced silencing complex (RISC). Recent work has provided our first glimpses of the RISC-assembly pathway and uncovered the biochemical roles of critical RISC components. These advances have taken our mechanistic understanding of RNA interference to a new level and promise to improve our ability to exploit this biological process for use in experimental biology and medicine.
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