Nitric oxide and redox signaling in allergic airway inflammation
- PMID: 15650402
- DOI: 10.1089/ars.2005.7.129
Nitric oxide and redox signaling in allergic airway inflammation
Abstract
A number of diseases of the respiratory tract, as exemplified in this review by asthma, are associated with increased amounts of nitric oxide (NO) in the expired breath. Asthma is furthermore characterized by increased production of reactive oxygen species that scavenge NO to form more reactive nitrogen species as demonstrated by the enhanced presence of nitrated proteins in the lungs of these patients. This increased oxidative metabolism leaves less bioavailable NO and coincides with lower amounts of S-nitrosothiols. In this review, we speculate on mechanisms responsible for the increased amounts of NO in inflammatory airway disease and discuss the apparent paradox of higher levels of NO as opposed to decreased amounts of S-nitrosothiols. We will furthermore give an overview of the regulation of NO production and biochemical events by which NO transduces signals into cellular responses, with a particular focus on modulation of inflammation by NO. Lastly, difficulties in studying NO signaling and possible therapeutic uses for NO will be highlighted.
Similar articles
-
Nitrative stress in inflammatory lung diseases.Nitric Oxide. 2011 Aug 1;25(2):138-44. doi: 10.1016/j.niox.2011.03.079. Epub 2011 Apr 2. Nitric Oxide. 2011. PMID: 21440655 Review.
-
Characterization of reactive nitrogen species in allergic asthma.Ann Allergy Asthma Immunol. 2014 Jan;112(1):18-22. doi: 10.1016/j.anai.2013.10.007. Epub 2013 Nov 6. Ann Allergy Asthma Immunol. 2014. PMID: 24331388 Review.
-
Reactive nitrogen species in the respiratory tract.Eur J Pharmacol. 2006 Mar 8;533(1-3):240-52. doi: 10.1016/j.ejphar.2005.12.057. Epub 2006 Feb 7. Eur J Pharmacol. 2006. PMID: 16464450 Review.
-
Proteinase activated receptor-2-mediated dual oxidase-2 up-regulation is involved in enhanced airway reactivity and inflammation in a mouse model of allergic asthma.Immunology. 2015 Jul;145(3):391-403. doi: 10.1111/imm.12453. Immunology. 2015. PMID: 25684443 Free PMC article.
-
Nitric oxide and cell signaling: modulation of redox tone and protein modification.Amino Acids. 2003 Dec;25(3-4):313-21. doi: 10.1007/s00726-003-0019-7. Epub 2003 Aug 28. Amino Acids. 2003. PMID: 14661093 Review.
Cited by
-
Bioanalytical profile of the L-arginine/nitric oxide pathway and its evaluation by capillary electrophoresis.J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 15;851(1-2):186-210. doi: 10.1016/j.jchromb.2007.02.011. Epub 2007 Feb 15. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 17329176 Free PMC article. Review.
-
Augmentation of S-Nitrosoglutathione Controls Cigarette Smoke-Induced Inflammatory-Oxidative Stress and Chronic Obstructive Pulmonary Disease-Emphysema Pathogenesis by Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function.Antioxid Redox Signal. 2017 Sep 1;27(7):433-451. doi: 10.1089/ars.2016.6895. Epub 2017 Feb 7. Antioxid Redox Signal. 2017. PMID: 28006950 Free PMC article.
-
Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma.Free Radic Biol Med. 2007 Mar 1;42(5):665-74. doi: 10.1016/j.freeradbiomed.2006.12.005. Epub 2006 Dec 14. Free Radic Biol Med. 2007. PMID: 17291990 Free PMC article. Clinical Trial.
-
Nitric oxide metabolism in asthma pathophysiology.Biochim Biophys Acta. 2011 Nov;1810(11):1008-16. doi: 10.1016/j.bbagen.2011.06.009. Epub 2011 Jun 21. Biochim Biophys Acta. 2011. PMID: 21718755 Free PMC article. Review.
-
Role of oxidative stress in female reproduction.Reprod Biol Endocrinol. 2005 Jul 14;3:28. doi: 10.1186/1477-7827-3-28. Reprod Biol Endocrinol. 2005. PMID: 16018814 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
