Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Jan;37(1):41-7.
doi: 10.1038/ng1484. Epub 2004 Dec 5.

Silencing of unsynapsed meiotic chromosomes in the mouse

James M A Turner  1 , Shantha K Mahadevaiah, Oscar Fernandez-Capetillo, André Nussenzweig, Xiaoling Xu, Chu-Xia Deng, Paul S Burgoyne
Affiliations

Silencing of unsynapsed meiotic chromosomes in the mouse

James M A Turner et al. Nat Genet. 2005 Jan.

Abstract

In Neurospora, DNA unpaired in meiosis both is silenced and induces silencing of all DNA homologous to it. This process, called meiotic silencing by unpaired DNA, is thought to protect the host genome from invasion by transposable elements. We now show that silencing of unpaired (unsynapsed) chromosome regions also takes place in the mouse during both male and female meiosis. The tumor suppressor protein BRCA1 is implicated in this silencing, mirroring its role in the meiotic silencing of the X and Y chromosomes in normal male meiosis. These findings impact on the interpretation of the relationship between synaptic errors and sterility in mammals and extend our understanding of the biology of Brca1.

PubMed Disclaimer

Comment in

  • Synapsis or silence.
    Schimenti J. Schimenti J. Nat Genet. 2005 Jan;37(1):11-3. doi: 10.1038/ng0105-11. Nat Genet. 2005. PMID: 15624015 No abstract available.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

MeSH terms

LinkOut - more resources