Review
doi: 10.1038/nrm1527.
AKAP signalling complexes: focal points in space and time
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- PMID: 15573134
- DOI: 10.1038/nrm1527
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Review
AKAP signalling complexes: focal points in space and time
Nat Rev Mol Cell Biol.
2004 Dec.
Abstract
Multiprotein signalling networks create focal points of enzyme activity that disseminate the intracellular action of many hormones and neurotransmitters. Accordingly, the spatio-temporal activation of protein kinases and phosphatases is an important factor in controlling where and when phosphorylation events occur. Anchoring proteins provide a molecular framework that orients these enzymes towards selected substrates. A-kinase anchoring proteins (AKAPs) are signal-organizing molecules that compartmentalize various enzymes that are regulated by second messengers.
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