Review
doi: 10.1016/j.chroma.2004.06.046.
Strategies for shotgun identification of post-translational modifications by mass spectrometry
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- PMID: 15543967
- DOI: 10.1016/j.chroma.2004.06.046
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Review
Strategies for shotgun identification of post-translational modifications by mass spectrometry
J Chromatogr A.
.
Abstract
The global identification of post-translationally modified proteins is a difficult challenge that is currently being addressed by many researchers in the field of mass spectrometry (MS)-based proteomics. The ability to identify thousands of proteins by shotgun-based strategies has made the mere idea of a global analysis of a particular protein modification seem reasonable. There has been much progress in the development of methods that make use of shotgun-based protein identification in the analysis of a wide variety of protein modifications, some of which will be discussed here.
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