Review
doi: 10.1078/0171-9335-00374.
The GGA proteins: key players in protein sorting at the trans-Golgi network
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- PMID: 15511083
- DOI: 10.1078/0171-9335-00374
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Review
The GGA proteins: key players in protein sorting at the trans-Golgi network
Eur J Cell Biol.
2004 Jul.
Abstract
The GGA (Golgi-localized, gamma-ear containing, ADP-ribosylation factor binding) family of multidomain coat proteins was first described in the year 2000. They are now known to occupy a central position in the trafficking of the mannose 6-phosphate receptors and other cargo molecules from the trans-Golgi network to the endosome/lysosome system. This review covers the recent structural and cell biological studies that have provided mechanistic insights into the function of the GGAs in mannose 6-phosphate receptor trafficking.
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