Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Nov;6(11):1071-81.
doi: 10.1038/ncb1180.

Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments

Alvar Trucco  1 , Roman S Polishchuk, Oliviano Martella, Alessio Di Pentima, Aurora Fusella, Daniele Di Giandomenico, Enrica San Pietro, Galina V Beznoussenko, Elena V Polishchuk, Massimiliano Baldassarre, Roberto Buccione, Willie J C Geerts, Abraham J Koster, Koert N J Burger, Alexander A Mironov, Alberto Luini
Affiliations

Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments

Alvar Trucco et al. Nat Cell Biol. 2004 Nov.

Abstract

The organization of secretory traffic remains unclear, mainly because of the complex structure and dynamics of the secretory pathway. We have thus studied a simplified system, a single synchronized traffic wave crossing an individual Golgi stack, using electron tomography. Endoplasmic-reticulum-to-Golgi carriers join the stack by fusing with cis cisternae and induce the formation of intercisternal tubules, through which they redistribute their contents throughout the stack. These tubules seem to be pervious to Golgi enzymes, whereas Golgi vesicles are depleted of both enzymes and cargo. Cargo then traverses the stack without leaving the cisternal lumen. When cargo exits the stack, intercisternal connections disappear. These findings provide a new view of secretory traffic that includes dynamic intercompartment continuities as key players.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources