Oscillations in NF-kappaB signaling control the dynamics of gene expression
- PMID: 15499023
- DOI: 10.1126/science.1099962
Oscillations in NF-kappaB signaling control the dynamics of gene expression
Abstract
Signaling by the transcription factor nuclear factor kappa B (NF-kappaB) involves its release from inhibitor kappa B (IkappaB) in the cytosol, followed by translocation into the nucleus. NF-kappaB regulation of IkappaBalpha transcription represents a delayed negative feedback loop that drives oscillations in NF-kappaB translocation. Single-cell time-lapse imaging and computational modeling of NF-kappaB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IkappaBalpha transcription. Transcription of target genes depended on oscillation persistence, involving cycles of RelA phosphorylation and dephosphorylation. The functional consequences of NF-kappaB signaling may thus depend on number, period, and amplitude of oscillations.
Comment in
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Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression".Science. 2005 Apr 1;308(5718):52; author reply 52. doi: 10.1126/science.1108198. Science. 2005. PMID: 15802586 Free PMC article. No abstract available.
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