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. 2004 Sep;10(9):1550-7.
doi: 10.3201/eid1009.040058.

Viral loads in clinical specimens and SARS manifestations

I F N Hung  1 , V C C Cheng, A K L Wu, B S F Tang, K H Chan, C M Chu, M M L Wong, W T Hui, L L M Poon, D M W Tse, K S Chan, P C Y Woo, S K P Lau, J S M Peiris, K Y Yuen
Affiliations

Viral loads in clinical specimens and SARS manifestations

I F N Hung et al. Emerg Infect Dis. 2004 Sep.

Abstract

A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.

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Figure
Serial change of the mean absolute lymphocyte count and immunoglobulin (Ig) G seroconversion of severe acute respiratory syndrome (SARS)–associated coronavirus in 154 SARS patients.
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