Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Oct;84(4):707-14.
doi: 10.1016/j.ygeno.2004.06.011.

Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15

Willie Wilson 3rd  1 , Fernando Pardo-Manuel de Villena, Beverly D Lyn-Cook, Pradeep K Chatterjee, Timothy A Bell, David A Detwiler, Rodney C Gilmore, Isis C Valladeras, Camille C Wright, David W Threadgill, Delores J Grant
Affiliations

Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15

Willie Wilson 3rd et al. Genomics. 2004 Oct.

Abstract

Members of the human UDP-glucuronosyltransferase 2B family are located in a cluster on chromosome 4q13 and code for enzymes whose gene products are responsible for the normal catabolism of steroid hormones. Two members of this family, UGT2B15 and UGT2B17, share over 95% sequence identity. However, UGT2B17 exhibits broader substrate specificity due to a single amino acid difference. Using gene-specific primers to explore the genomic organization of these two genes, it was determined that UGT2B17 is absent in some human DNA samples. The gene-specific primers demonstrated the presence or absence of a 150 kb genomic interval spanning the entire UGT2B17 gene, revealing that UGT2B17 is present in the human genome as a deletion polymorphism linked to UGT2B15. Furthermore, it is shown that the UGT2B17 deletion polymorphism shows Mendelian segregation and allele frequencies that differ between African Americans and Caucasians.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources