Comparative Study
doi: 10.1002/ana.20268.
alpha-Synuclein promoter confers susceptibility to Parkinson's disease
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- PMID: 15455394
- DOI: 10.1002/ana.20268
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Comparative Study
alpha-Synuclein promoter confers susceptibility to Parkinson's disease
Ann Neurol.
2004 Oct.
Abstract
Familial Parkinson's disease (PD) has been linked to missense and genomic multiplication mutations of the alpha-synuclein gene (SNCA). Genetic variability within SNCA has been implicated in idiopathic PD in many populations. We now confirm and extend these findings, within a Belgian sample, using a high-resolution map of genetic markers across the SNCA locus. Our study implicates the SNCA promoter in susceptibility to PD, and more specifically defines a minimum promoter haplotype, spanning approximately 15.3kb of sequence, which is overrepresented in patients. Our findings represent a biomarker for PD and may have implications for patient diagnosis, longitudinal evaluation, and treatment.
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