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Review
. 2004 Nov 15;71(2):343-54.
doi: 10.1002/jbm.b.30096.

Antigenicity and immunogenicity of collagen

Affiliations
Review

Antigenicity and immunogenicity of collagen

A K Lynn et al. J Biomed Mater Res B Appl Biomater. .

Abstract

Pertinent issues of collagen antigenicity and immunogenicity are concisely reviewed as they relate to the design and application of biomedical devices. A brief discussion of the fundamental concepts of collagen immunochemistry is presented, with a subsequent review of documented clinical responses to devices containing reconstituted soluble or solubilized collagen. The significance of atelocollagen, concerns regarding collagen-induced autoimmunity, and other relevant topics are also addressed in the context of current understanding of the human immune response to collagen.

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