Antigenicity and immunogenicity of collagen
- PMID: 15386396
- DOI: 10.1002/jbm.b.30096
Antigenicity and immunogenicity of collagen
Abstract
Pertinent issues of collagen antigenicity and immunogenicity are concisely reviewed as they relate to the design and application of biomedical devices. A brief discussion of the fundamental concepts of collagen immunochemistry is presented, with a subsequent review of documented clinical responses to devices containing reconstituted soluble or solubilized collagen. The significance of atelocollagen, concerns regarding collagen-induced autoimmunity, and other relevant topics are also addressed in the context of current understanding of the human immune response to collagen.
(c) 2004 Wiley Periodicals, Inc.
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