Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells
- PMID: 15381647
- DOI: 10.1161/01.CIR.0000142616.07367.66
Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells
Abstract
Background: Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists.
Methods and results: Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia.
Conclusions: G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization.
Comment in
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Letter regarding article by Shyu et al, "functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells".Circulation. 2005 May 17;111(19):e297-8; author reply e297-8. doi: 10.1161/01.CIR.0000165120.35950.C7. Circulation. 2005. PMID: 15897352 No abstract available.
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