Free radicals in cell biology
- PMID: 15380666
- DOI: 10.1016/S0074-7696(04)37002-6
Free radicals in cell biology
Abstract
In aerobic cells, free radicals are constantly produced mostly as reactive oxygen species. Once produced, free radicals are removed by antioxidant defenses including enzyme catalase, glutathione peroxidase, and superoxide dismutase. Reactive oxygen species, including nitric oxide and related species, commonly exert a series of useful physiological effects. However, imbalance between prooxidant and antioxidant defenses in favor of prooxidants results in oxidative stress associated with the oxidative modification of biomolecules such as lipids, proteins, and nucleic acids. Alone or in combination with primary ethiological factors, free radicals are involved in a pathogenesis of more than a hundred diseases. This chapter reviews the basic science of some of the potential sources and characteristics of free radicals, as well as antioxidant enzymes. Special attention is paid to the role of free radicals in the pathogenesis of atherosclerosis and immunology-mediated inflammatory reaction.
Similar articles
-
Free radicals, metals and antioxidants in oxidative stress-induced cancer.Chem Biol Interact. 2006 Mar 10;160(1):1-40. doi: 10.1016/j.cbi.2005.12.009. Epub 2006 Jan 23. Chem Biol Interact. 2006. PMID: 16430879 Review.
-
[Free oxygen radiacals and kidney diseases--part I].Med Pregl. 2000 Sep-Oct;53(9-10):463-74. Med Pregl. 2000. PMID: 11320727 Review. Croatian.
-
Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system.Ann N Y Acad Sci. 2001 Jun;939:200-15. Ann N Y Acad Sci. 2001. PMID: 11462772 Review.
-
[Free radicals and antioxidants: human physiology, pathology and therapeutic aspects].Therapie. 1997 Jul-Aug;52(4):251-70. Therapie. 1997. PMID: 9437876 Review. French.
-
[Chosen non-enzymatic substances that participate in a protection against overproduction of free radicals].Pol Merkur Lekarski. 2008 Sep;25(147):269-72. Pol Merkur Lekarski. 2008. PMID: 19112847 Review. Polish.
Cited by
-
Protective effects of dietary carotenoids on risk of hip fracture in men: the Singapore Chinese Health Study.J Bone Miner Res. 2014 Feb;29(2):408-17. doi: 10.1002/jbmr.2041. J Bone Miner Res. 2014. PMID: 23857780 Free PMC article.
-
Anti-Fatigue Effects of Fermented Rhodiola rosea Extract in Mice.Prev Nutr Food Sci. 2015 Mar;20(1):38-42. doi: 10.3746/pnf.2015.20.1.38. Epub 2015 Mar 31. Prev Nutr Food Sci. 2015. PMID: 25866748 Free PMC article.
-
A step forward in the development of superoxide dismutase mimetic nanozymes: the effect of the charge of the surface on antioxidant activity.RSC Adv. 2019 Dec 16;9(71):41549-41560. doi: 10.1039/c9ra08992f. eCollection 2019 Dec 13. RSC Adv. 2019. PMID: 35541615 Free PMC article.
-
Mechanism of Hepatoprotective Effect of Boesenbergia rotunda in Thioacetamide-Induced Liver Damage in Rats.Evid Based Complement Alternat Med. 2013;2013:157456. doi: 10.1155/2013/157456. Epub 2013 Aug 7. Evid Based Complement Alternat Med. 2013. Retraction in: Evid Based Complement Alternat Med. 2018 Jul 18;2018:1072403. doi: 10.1155/2018/1072403 PMID: 23997791 Free PMC article. Retracted.
-
Zanthoxylum Species: A Comprehensive Review of Traditional Uses, Phytochemistry, Pharmacological and Nutraceutical Applications.Molecules. 2021 Jun 30;26(13):4023. doi: 10.3390/molecules26134023. Molecules. 2021. PMID: 34209371 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
