Migration pathways and immunologic memory among T lymphocytes
- PMID: 1534264
Migration pathways and immunologic memory among T lymphocytes
Abstract
The lymphatic and circulatory systems are essential channels for the dissemination of memory cells throughout the body. However, the migration of naive and memory T cells through these channels is not random. Naive-type T cells preferentially migrate from blood to lymph nodes whereas memory T cells preferentially migrate to tissues, particularly those with a high exposure to antigen. The large-scaled migration of naive T cells through lymph nodes increases the likelihood of these T cells encountering a primary antigen, and brings them in contact with other players, particularly antigen presenting cells. On the other hand, the migration of memory T cells to tissues such as skin or gut mucosa serves to provide an immediate protection in an environment where antigen is likely to be re-encountered. The migration of memory T cells is further rationalized, in that phenotypically distinct subsets of memory T cells migrate to specific tissues. The migration of lymphocytes through the body is controlled by adhesion molecules on the surface of lymphocytes, which interact with receptors on the surface of endothelium, and it is the differential expression of these molecules which in part controls the different migration streams of T cells through the body.
Similar articles
-
Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells.Eur J Immunol. 1992 Apr;22(4):887-95. doi: 10.1002/eji.1830220402. Eur J Immunol. 1992. PMID: 1372559
-
Differential expression of homing-associated adhesion molecules by T cell subsets in man.J Immunol. 1990 Nov 15;145(10):3247-55. J Immunol. 1990. PMID: 1700003
-
The migratory behavior of murine CD4+ cells of memory phenotype.Eur J Immunol. 1997 Sep;27(9):2225-32. doi: 10.1002/eji.1830270916. Eur J Immunol. 1997. PMID: 9341763
-
Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues.Mol Immunol. 2005 May;42(7):799-809. doi: 10.1016/j.molimm.2004.06.040. Epub 2004 Nov 23. Mol Immunol. 2005. PMID: 15829268 Review.
-
Function of CD4 T cell subsets in vivo: expression of CD45R isoforms.Semin Immunol. 1992 Feb;4(1):43-50. Semin Immunol. 1992. PMID: 1534263 Review.
Cited by
-
Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease.Arthritis Res Ther. 2004;6(5):R433-46. doi: 10.1186/ar1212. Epub 2004 Jul 19. Arthritis Res Ther. 2004. PMID: 15380043 Free PMC article.
-
Enhanced responsiveness to antigen contributes more to immunological memory in CD4 T cells than increases in the number of cells.Immunology. 2005 Nov;116(3):318-27. doi: 10.1111/j.1365-2567.2005.02227.x. Immunology. 2005. PMID: 16236121 Free PMC article.
-
A Chlamydia trachomatis-specific Th2 clone does not provide protection against a genital infection and displays reduced trafficking to the infected genital mucosa.Infect Immun. 2002 Sep;70(9):5132-9. doi: 10.1128/IAI.70.9.5132-5139.2002. Infect Immun. 2002. PMID: 12183563 Free PMC article.
-
T cell signaling mechanisms that regulate HIV-1 infection.Immunol Res. 2001;23(2-3):167-77. doi: 10.1385/IR:23:2-3:167. Immunol Res. 2001. PMID: 11444382
-
Expression pattern of HIV-1 coreceptors on T cells: implications for viral transmission and lymphocyte homing.Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1615-8. doi: 10.1073/pnas.94.5.1615. Proc Natl Acad Sci U S A. 1997. PMID: 9050826 Free PMC article. No abstract available.