SOS response induction by beta-lactams and bacterial defense against antibiotic lethality
- PMID: 15308764
- DOI: 10.1126/science.1101630
SOS response induction by beta-lactams and bacterial defense against antibiotic lethality
Abstract
The SOS response aids bacterial propagation by inhibiting cell division during repair of DNA damage. We report that inactivation of the ftsI gene product, penicillin binding protein 3, by either beta-lactam antibiotics or genetic mutation induces SOS in Escherichia coli through the DpiBA two-component signal transduction system. This event, which requires the SOS-promoting recA and lexA genes as well as dpiA, transiently halts bacterial cell division, enabling survival to otherwise lethal antibiotic exposure. Our findings reveal defective cell wall synthesis as an unexpected initiator of the bacterial SOS response, indicate that beta-lactam antibiotics are extracellular stimuli of this response, and demonstrate a novel mechanism for mitigation of antimicrobial lethality.
Comment in
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Microbiology. Noninherited resistance to antibiotics.Science. 2004 Sep 10;305(5690):1578-9. doi: 10.1126/science.1103077. Science. 2004. PMID: 15361616 No abstract available.
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