Comparative Study
doi: 10.1126/science.1529340.
MacroH2A, a core histone containing a large nonhistone region
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- PMID: 1529340
- DOI: 10.1126/science.1529340
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Comparative Study
MacroH2A, a core histone containing a large nonhistone region
Science.
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Abstract
A histone, macroH2A, nearly three times the size of conventional H2A histone, was found in rat liver nucleosomes. Its N-terminal third is 64 percent identical to a full-length mouse H2A. However, it also contains a large nonhistone region. This region has a segment that resembles a leucine zipper, a structure known to be involved in dimerization of some transcription factors. Nucleosomes containing macroH2A may have novel functions, possibly involving interactions with other nuclear proteins.
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