Regulation of histone acetylation during memory formation in the hippocampus
- PMID: 15273246
- DOI: 10.1074/jbc.M402229200
Regulation of histone acetylation during memory formation in the hippocampus
Abstract
Formation of long term memory begins with the activation of many disparate signaling pathways that ultimately impinge on the cellular mechanisms regulating gene expression. We investigated whether mechanisms regulating chromatin structure were activated during the early stages of long term memory formation in the hippocampus. Specifically, we investigated hippocampal histone acetylation during the initial stages of consolidation of long term association memories in a contextual fear conditioning paradigm. Acetylation of histone H3 in area CA1 of the hippocampus was regulated in contextual fear conditioning, an effect dependent on activation of N-methyl-D-aspartic acid (NMDA) receptors and ERK, and blocked using a behavioral latent inhibition paradigm. Activation of NMDA receptors in area CA1 in vitro increased acetylation of histone H3, and this effect was blocked by inhibition of ERK signaling. Moreover, activation of ERK in area CA1 in vitro through either the protein kinase C or protein kinase A pathways, biochemical events known to be involved in long term memory formation, also increased histone H3 acetylation. Furthermore, we observed that elevating levels of histone acetylation through the use of the histone deacetylase inhibitors trichostatin A or sodium butyrate enhanced induction of long term potentiation at Schaffer-collateral synapses in area CA1 of the hippocampus, a candidate mechanism contributing to long term memory formation in vivo. In concert with our findings in vitro, injection of animals with sodium butyrate prior to contextual fear conditioning enhanced formation of long term memory. These results indicate that histone-associated heterochromatin undergoes changes in structure during the formation of long term memory. Mimicking memory-associated changes in heterochromatin enhances a cellular process thought to underlie long term memory formation, hippocampal long term potentiation, and memory formation itself.
Copyright 2004 American Society for Biochemistry and Molecular Biology, Inc.
Similar articles
-
ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning.Learn Mem. 2006 May-Jun;13(3):322-8. doi: 10.1101/lm.152906. Learn Mem. 2006. PMID: 16741283 Free PMC article.
-
Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene.J Psychiatr Res. 2012 May;46(5):635-43. doi: 10.1016/j.jpsychires.2012.01.026. Epub 2012 Feb 25. J Psychiatr Res. 2012. PMID: 22364833
-
The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and stress-activated kinase signalling pathway.Eur J Neurosci. 2008 May;27(10):2701-13. doi: 10.1111/j.1460-9568.2008.06230.x. Epub 2008 May 29. Eur J Neurosci. 2008. PMID: 18513320
-
[Novel therapeutic approach for the treatment of post-traumatic stress disorder (PTSD): facilitating fear extinction].Nihon Shinkei Seishin Yakurigaku Zasshi. 2012 Aug;32(4):195-201. Nihon Shinkei Seishin Yakurigaku Zasshi. 2012. PMID: 23012887 Review. Japanese.
-
Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase.Prog Brain Res. 2008;169:97-115. doi: 10.1016/S0079-6123(07)00006-4. Prog Brain Res. 2008. PMID: 18394470 Free PMC article. Review.
Cited by
-
Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain.Genet Med. 2021 Aug;23(8):1465-1473. doi: 10.1038/s41436-021-01152-7. Epub 2021 Apr 8. Genet Med. 2021. PMID: 33833410 Free PMC article.
-
The circadian clock: a framework linking metabolism, epigenetics and neuronal function.Nat Rev Neurosci. 2013 Jan;14(1):69-75. doi: 10.1038/nrn3393. Epub 2012 Nov 28. Nat Rev Neurosci. 2013. PMID: 23187814 Free PMC article. Review.
-
Why estrogens matter for behavior and brain health.Neurosci Biobehav Rev. 2017 May;76(Pt B):363-379. doi: 10.1016/j.neubiorev.2016.03.024. Epub 2016 Mar 31. Neurosci Biobehav Rev. 2017. PMID: 27039345 Free PMC article. Review.
-
Visual cortex plasticity: a complex interplay of genetic and environmental influences.Neural Plast. 2012;2012:631965. doi: 10.1155/2012/631965. Epub 2012 Jul 18. Neural Plast. 2012. PMID: 22852098 Free PMC article. Review.
-
Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders.Neural Plast. 2016;2016:4235898. doi: 10.1155/2016/4235898. Epub 2016 Jul 28. Neural Plast. 2016. PMID: 27547454 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous