doi: 10.1021/ja040022b.
The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4
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- PMID: 15250722
- DOI: 10.1021/ja040022b
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The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4
J Am Chem Soc.
.
Abstract
The nuclease hypersensitivity element III1 (NHE III1) upstream of the P1 and P2 promoters of c-MYC controls 80-90% of the transcriptional activity of this gene. The purine-rich strand in this region can form a G-quadruplex structure that is a critical part of the silencer element for this promoter. We have demonstrated that this G-quadruplex structure can form a mixture of four biologically relevant parallel-loop isomers, which upon interaction with the cationic porphyrin TMPyP4 are converted to mixed parallel/antiparallel G-quadruplex structures.
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