Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer's patches
- PMID: 15210762
- DOI: 10.4049/jimmunol.173.1.86
Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer's patches
Abstract
Organogenesis of Peyer's patches (PP), follicle-associated epithelium, and M cells is impaired in mice lacking B cells. At the same time, lymphotoxin (LT) and TNF are known to be critical for the development of PP. To directly address the function of LT and TNF expressed by B cells in the maintenance of PP structure, we studied the de novo formation of PP in B cell-deficient mice after the transfer of bone marrow from mice with targeted mutations in LT, TNF, or their combinations. We found that although the compartmentalization of T and B cell zones and development of follicular dendritic cells were affected by the lack of B cell-derived LT and TNF, the development of follicle-associated epithelium and M cells in PP was completely independent of LT/TNF production by B cells.
Similar articles
-
Peyer's patch organogenesis--cytokines rule, OK?Gut. 1997 Nov;41(5):707-9. doi: 10.1136/gut.41.5.707. Gut. 1997. PMID: 9414984 Free PMC article. Review.
-
Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor.Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6319-23. doi: 10.1073/pnas.94.12.6319. Proc Natl Acad Sci U S A. 1997. PMID: 9177215 Free PMC article.
-
Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract.J Immunol. 2000 May 15;164(10):5184-91. doi: 10.4049/jimmunol.164.10.5184. J Immunol. 2000. PMID: 10799877
-
Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue.Eur J Immunol. 1997 Oct;27(10):2600-9. doi: 10.1002/eji.1830271020. Eur J Immunol. 1997. PMID: 9368616
-
Cytokine regulation of secondary lymphoid organ development.Curr Opin Immunol. 1998 Jun;10(3):289-97. doi: 10.1016/s0952-7915(98)80167-2. Curr Opin Immunol. 1998. PMID: 9638365 Review.
Cited by
-
Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function.Semin Immunol. 2008 Feb;20(1):14-25. doi: 10.1016/j.smim.2007.12.001. Epub 2008 Feb 7. Semin Immunol. 2008. PMID: 18261920 Free PMC article. Review.
-
Re-thinking the functions of IgA(+) plasma cells.Gut Microbes. 2014;5(5):652-62. doi: 10.4161/19490976.2014.969977. Gut Microbes. 2014. PMID: 25483334 Free PMC article. Review.
-
Sampling of the intestinal microbiota by epithelial M cells.Curr Gastroenterol Rep. 2010 Oct;12(5):331-9. doi: 10.1007/s11894-010-0128-x. Curr Gastroenterol Rep. 2010. PMID: 20706806 Review.
-
Induction of intestinal lymphoid tissue formation by intrinsic and extrinsic signals.Semin Immunopathol. 2009 Jul;31(2):151-69. doi: 10.1007/s00281-009-0163-6. Epub 2009 Jun 9. Semin Immunopathol. 2009. PMID: 19506873 Review.
-
Effects of acute and chronic inflammation on B-cell development and differentiation.J Invest Dermatol. 2009 Feb;129(2):266-77. doi: 10.1038/jid.2008.286. J Invest Dermatol. 2009. PMID: 19148216 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous
