Immunohistochemical study of serotonin in lesions of psoriasis
- PMID: 15186219
- DOI: 10.1111/j.1365-4632.2004.02195.x
Immunohistochemical study of serotonin in lesions of psoriasis
Abstract
Objective: To study the role of serotonin in the pathogenesis of psoriasis.
Methods: Immunohistochemical techniques were used to study the expression of serotonin in the lesions of patients with psoriasis.
Results: Expression of serotonin was significantly stronger in the prickle cells, sweat gland cells, sebaceous gland cells, and hair roots of the lesions in the progressive stage of psoriasis than in the static stage. There was no difference in serotonin expression between the vulgaris type and the pustular type. No expression of serotonin occurred in the specimens of normal skin.
Conclusion: Serotonin probably plays an important role in the pathogenesis and activity of psoriasis.
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