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. 2004 Jun 4;304(5676):1515-8.
doi: 10.1126/science.1098371.

A process for controlling intracellular bacterial infections induced by membrane injury

Deepannita Roy  1 , David R Liston, Vincent J Idone, Anke Di, Deborah J Nelson, Céline Pujol, James B Bliska, Sabyasachi Chakrabarti, Norma W Andrews
Affiliations

A process for controlling intracellular bacterial infections induced by membrane injury

Deepannita Roy et al. Science. .

Abstract

Strategies for inhibiting phagolysosome fusion are essential for the intracellular survival and replication of many pathogens. We found that the lysosomal synaptotagmin Syt VII is required for a mechanism that promotes phagolysosomal fusion and limits the intracellular growth of pathogenic bacteria. Syt VII was required for a form of Ca2+-dependent phagolysosome fusion that is analogous to Ca2+-regulated exocytosis of lysosomes, which can be triggered by membrane injury. Bacterial type III secretion systems, which permeabilize membranes and cause Ca2+ influx in mammalian cells, promote lysosomal exocytosis and inhibit intracellular survival in Syt VII +/+ but not -/- cells. Thus, the lysosomal repair response can also protect cells against pathogens that trigger membrane permeabilization.

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