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Review
. 2004 Jun 1;90(11):2053-8.
doi: 10.1038/sj.bjc.6601705.

Role of infiltrated leucocytes in tumour growth and spread

E Y Lin  1 , J W Pollard
Affiliations
Review

Role of infiltrated leucocytes in tumour growth and spread

E Y Lin et al. Br J Cancer. .

Abstract

Leucocytes are a major component of the tumour microenvironment. Recent studies have indicated that the infiltration and activity of these host cells are regulated by the tumour to promote its survival and progression. Through the production of an array of growth factors, proteases and angiogenic mediators, leucocytes in the tumour microenvironment promote tumour growth, angiogenesis and metastasis.

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Figures

Figure 1
Figure 1
Leucocytic infiltration promotes tumour progression to malignancy. In a manner similar to wounded tissues, solid tumours induce a local ‘inflammatory response’ by attracting leucocytes into its microenvironment. Such an infiltration consists of multiple cell types of which cells of the myeloid lineage are the major component. Leucocytes in such ‘inflammatory sites’ produce an array of growth and angiogenic factors, proteases and mutagenic factors that promote tumour growth, invasion and angiogenesis. However, different from its physiological counterpart whose inflammation ceases when the wound has healed, tumour-induced inflammation persists and eventually leads to tumour progression and metastasis.
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