Death in the third dimension: apoptosis regulation and tissue architecture
- PMID: 15108808
- DOI: 10.1016/j.gde.2003.12.005
Death in the third dimension: apoptosis regulation and tissue architecture
Abstract
Tissue development, homeostasis and tumor pathogenesis all depend upon a complex dialogue between multiple cell types operating within a dynamic three-dimensional (3D) tissue extracellular matrix microenvironment. A major issue is whether the spatial organization of a cell within this 3D tissue microenvironment could modulate cell responsiveness to regulate cell fate decisions such as survival, and if so how. Classic developmental model systems and transgenic animals are instructive but pose special challenges for investigators conducting signaling studies and biochemical assays in tissues. As an alternative, 3D culture model systems exist in which cell-adhesion dependent tissue architecture, heterotypic cell-cell interactions and tissue differentiation can be recapitulated with good fidelity. 3D cell culture models are slowly revealing how tissue architecture can dramatically influence how a cell responds to exogenous stimuli to modify its apoptotic behavior and hence should prove instrumental for identifying novel cell death pathways.
Similar articles
-
Three-dimensional tissue culture models in cancer biology.Semin Cancer Biol. 2005 Oct;15(5):365-77. doi: 10.1016/j.semcancer.2005.05.002. Semin Cancer Biol. 2005. PMID: 15975824 Review.
-
Cell survival in a three-dimensional matrix.Methods Enzymol. 2007;426:85-101. doi: 10.1016/S0076-6879(07)26005-7. Methods Enzymol. 2007. PMID: 17697881 Review.
-
Living in three dimensions: 3D nanostructured environments for cell culture and regenerative medicine.Cell Biochem Biophys. 2006;45(2):215-27. doi: 10.1385/CBB:45:2:215. Cell Biochem Biophys. 2006. PMID: 16757822 Review.
-
Effect of 3D scaffold and dynamic culture condition on the global gene expression profile of mouse embryonic stem cells.Biomaterials. 2006 Dec;27(36):5978-89. doi: 10.1016/j.biomaterials.2006.05.053. Epub 2006 Jul 7. Biomaterials. 2006. PMID: 16824594
-
Mechanobiology in the third dimension.Ann Biomed Eng. 2005 Nov;33(11):1469-90. doi: 10.1007/s10439-005-8159-4. Ann Biomed Eng. 2005. PMID: 16341917 Review.
Cited by
-
Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth.Genes Dev. 2004 Sep 15;18(18):2243-8. doi: 10.1101/gad.303304. Genes Dev. 2004. PMID: 15371338 Free PMC article.
-
Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties.Phys Biol. 2011 Apr;8(2):026013. doi: 10.1088/1478-3975/8/2/026013. Epub 2011 Mar 25. Phys Biol. 2011. PMID: 21441648 Free PMC article.
-
A study with cancer stem cells and three-dimensional tumoroids: investigation of the combined effects of 5-fluorouracil and doxorubicin in breast cancer.Med Oncol. 2024 Jun 23;41(7):185. doi: 10.1007/s12032-024-02423-4. Med Oncol. 2024. PMID: 38910198 Free PMC article.
-
Microengineered systems with iPSC-derived cardiac and hepatic cells to evaluate drug adverse effects.Exp Biol Med (Maywood). 2021 Feb;246(3):317-331. doi: 10.1177/1535370220959598. Epub 2020 Sep 17. Exp Biol Med (Maywood). 2021. PMID: 32938227 Free PMC article. Review.
-
In vitro optimization of EtNBS-PDT against hypoxic tumor environments with a tiered, high-content, 3D model optical screening platform.Mol Pharm. 2012 Nov 5;9(11):3171-82. doi: 10.1021/mp300262x. Epub 2012 Oct 11. Mol Pharm. 2012. PMID: 22946843 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
