Non-Alzheimer's disease dementias: anatomic, clinical, and molecular correlates
- PMID: 15101498
- DOI: 10.1177/070674370404900303
Non-Alzheimer's disease dementias: anatomic, clinical, and molecular correlates
Abstract
Objective: To review the clinical and molecular features of non-Alzheimer's disease (non-AD) dementias, focusing on disorders associated with tau pathology (that is, frontotemporal lobar degeneration [FTLD], corticobasal ganglionic degeneration [CBD], and progressive supranuclear palsy [PSP]) or on disorders with synuclein pathology (that is, dementia with Lewy bodies [DLB] and multisystem atrophy [MSA]). We also discuss the pharmacologic treatment of these disorders.
Methods: We report a selective review of the literature on FTLD, CBD, PSP, DLB, and MSA.
Results: The non-AD dementias can present with a wide variety of cognitive and behavioural symptoms. Through common clinical features and shared molecular etiologies, neurodegenerative disorders previously thought to be distinct are now classified into tauopathies and synucleinopathies.
Conclusions: The unique cognitive and behavioural manifestations of the non-AD dementias can be mistaken for psychiatric disorders. Improved detection of tauopathies and synucleinopathies and their differentiation from AD is possible.
Comment in
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Neuropsychiatry: grasping the body-mind and mind-body problems.Can J Psychiatry. 2004 Mar;49(3):155-6. doi: 10.1177/070674370404900301. Can J Psychiatry. 2004. PMID: 15101496 No abstract available.
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