Differential loss of ancestral gene families as a source of genomic divergence in animals

doi:10.1098/rsbl.2003.0124

Comparative Study

. 2004 Feb 7;271 Suppl 3(Suppl 3):S107-9.

doi: 10.1098/rsbl.2003.0124.

Differential loss of ancestral gene families as a source of genomic divergence in animals

Austin L Hughes¹, Robert Friedman

Affiliations

Affiliation

¹ Department of Biological Sciences, University of South Carolina, Coker Life Sciences Building, 700 Sumter Street, Columbia, SC 29208, USA. austin@biol.sc.edu

PMID: 15101434
PMCID: PMC1809979
DOI: 10.1098/rsbl.2003.0124

Comparative Study

Differential loss of ancestral gene families as a source of genomic divergence in animals

Austin L Hughes et al. Proc Biol Sci. 2004.

. 2004 Feb 7;271 Suppl 3(Suppl 3):S107-9.

doi: 10.1098/rsbl.2003.0124.

Authors

Austin L Hughes¹, Robert Friedman

Affiliation

¹ Department of Biological Sciences, University of South Carolina, Coker Life Sciences Building, 700 Sumter Street, Columbia, SC 29208, USA. austin@biol.sc.edu

PMID: 15101434
PMCID: PMC1809979
DOI: 10.1098/rsbl.2003.0124

Abstract

A phylogenetic approach was used to reconstruct the pattern of an apparent loss of 2106 ancestral gene families in four animal genomes (Caenorhabditis elegans, Drosophila melanogaster, human and fugu). Substantially higher rates of loss of ancestral gene families were found in the invertebrates than in the vertebrates. These results indicate that the differential loss of ancestral gene families can be a significant factor in the evolutionary diversification of organisms.

PubMed Disclaimer

Cited by

Computational methods for Gene Orthology inference.
Kristensen DM, Wolf YI, Mushegian AR, Koonin EV. Kristensen DM, et al. Brief Bioinform. 2011 Sep;12(5):379-91. doi: 10.1093/bib/bbr030. Epub 2011 Jun 19. Brief Bioinform. 2011. PMID: 21690100 Free PMC article.
Gene duplication and the properties of biological networks.
Hughes AL, Friedman R. Hughes AL, et al. J Mol Evol. 2005 Dec;61(6):758-64. doi: 10.1007/s00239-005-0037-z. Epub 2005 Nov 2. J Mol Evol. 2005. PMID: 16315107 Free PMC article.
Shedding genomic ballast: extensive parallel loss of ancestral gene families in animals.
Hughes AL, Friedman R. Hughes AL, et al. J Mol Evol. 2004 Dec;59(6):827-33. doi: 10.1007/s00239-004-0115-7. J Mol Evol. 2004. PMID: 15599514
The vertebrate phylotypic stage and an early bilaterian-related stage in mouse embryogenesis defined by genomic information.
Irie N, Sehara-Fujisawa A. Irie N, et al. BMC Biol. 2007 Jan 12;5:1. doi: 10.1186/1741-7007-5-1. BMC Biol. 2007. PMID: 17222327 Free PMC article.
Gene loss and parallel evolution contribute to species difference in flower color.
Smith SD, Rausher MD. Smith SD, et al. Mol Biol Evol. 2011 Oct;28(10):2799-810. doi: 10.1093/molbev/msr109. Epub 2011 May 6. Mol Biol Evol. 2011. PMID: 21551271 Free PMC article.

See all "Cited by" articles

References

1. Mol Biol Evol. 1989 Nov;6(6):559-79 - PubMed
1. Cell. 1993 Mar 26;72(6):823-6 - PubMed
1. Mol Biol Evol. 1997 Jan;14(1):1-5 - PubMed
1. Nature. 1997 May 29;387(6632):489-93 - PubMed
1. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7799-806 - PubMed

Publication types

Actions
Actions

MeSH terms

Grants and funding

GM066710/GM/NIGMS NIH HHS/United States

LinkOut - more resources

Full Text Sources
Molecular Biology Databases
- FlyBase

[1] Mol Biol Evol. 1989 Nov;6(6):559-79 - PubMed

[2] Mol Biol Evol. 1989 Nov;6(6):559-79 - PubMed

[3] Cell. 1993 Mar 26;72(6):823-6 - PubMed

[4] Cell. 1993 Mar 26;72(6):823-6 - PubMed

[5] Mol Biol Evol. 1997 Jan;14(1):1-5 - PubMed

[6] Mol Biol Evol. 1997 Jan;14(1):1-5 - PubMed

[7] Nature. 1997 May 29;387(6632):489-93 - PubMed

[8] Nature. 1997 May 29;387(6632):489-93 - PubMed

[9] Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7799-806 - PubMed

[10] Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7799-806 - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Differential loss of ancestral gene families as a source of genomic divergence in animals

Affiliation

Differential loss of ancestral gene families as a source of genomic divergence in animals

Authors

Affiliation

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Molecular Biology Databases