Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 May;6(3):180-5.
doi: 10.1007/s11883-004-0030-9.

Antidiabetic actions of estrogen: insight from human and genetic mouse models

Jean-Francois Louet  1 , Cedric LeMay, Franck Mauvais-Jarvis
Affiliations
Review

Antidiabetic actions of estrogen: insight from human and genetic mouse models

Jean-Francois Louet et al. Curr Atheroscler Rep. 2004 May.

Abstract

There is increasing evidence both in humans and rodents linking the endogenous estrogen 17b-estradiol (E2) to the maintenance of glucose homeostasis. Postmenopausal women develop visceral obesity and insulin resistance and are at increased risk for type 2 diabetes mellitus, but hormone replacement therapy leads to a reduction in the incidence of diabetes. In various spontaneous rodent models of type 2 diabetes, female rodents are protected against hyperglycemia unless they are ovariectomized, and E2 perfusion reverses diabetes in male rodents. Finally, the study of transgenic mice and mice with genetic alteration of E2 secretion or E2 action has shed light on the antidiabetic properties of E2 at a tissue-specific level. Thus, E2 secretion and action in rodents seems to be implicated 1) in adipose tissue biology and the prevention of obesity, 2) in the stimulation of liver fatty acid metabolism and suppression of hepatic glucose production, and 3) in the protection of pancreatic b-cell function/survival and insulin secretion in conditions of oxidative stress.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Clin Endocrinol Metab. 2001 Jan;86(1):48-52 - PubMed
    1. Diabetes. 2003 Jan;52(1):1-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4728-32 - PubMed
    1. Fertil Steril. 2003 Mar;79(3):550-5 - PubMed
    1. Endocrinology. 2004 Apr;145(4):1842-8 - PubMed

LinkOut - more resources