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. 2004 May 27;23(25):4371-9.
doi: 10.1038/sj.onc.1207583.

Binding of RNA to p53 regulates its oligomerization and DNA-binding activity

Yoichiro Yoshida  1 , Hiroto Izumi, Takayuki Torigoe, Hiroshi Ishiguchi, Takeshi Yoshida, Hideaki Itoh, Kimitoshi Kohno
Affiliations

Binding of RNA to p53 regulates its oligomerization and DNA-binding activity

Yoichiro Yoshida et al. Oncogene. .

Abstract

The C-terminus of p53 is responsible for maintaining the latent, non-DNA-binding form of p53. However, the mechanism by which the C-terminus regulates DNA binding is not yet fully understood. We show here that p53 interacts with RNA via its C-terminal domain and that disruption of this interaction, by RNase A treatment, truncation or phosphorylation of the C-terminus, restores DNA-binding activity. Furthermore, the oligomerization of p53 is significantly enhanced by disrupting the interaction between p53 and RNA. These findings suggest that binding of RNA to p53 is involved in the mechanism of p53 latency.

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