The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus
- PMID: 15048726
- DOI: 10.1002/eji.200324449
The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus
Abstract
Toll-like receptors (TLR) and IL-12 represent key elements of innate immunity. Using C57BL/10 ScCr mice it was shown that TLR4 is important for control of infection with respiratory syncytial virus (RSV). Since these mice have an additional defect in the IL-12R, we reinvestigated immunity to RSV in several C57BL/10 and BALB/c mouse strains lacking a functional TLR4, a functional IL-12-IL-12R interaction or both. In the absence of a functional IL-12 axis, early virus control was impaired in C57BL/10 mice, but not in BALB/c mice. By contrast, TLR4 had no impact on RSV elimination. Pulmonary NK cell recruitment was impaired in IL-12 deficient BALB/c mice and NK cytotoxicity was reduced in IL-12/IL-12R-deficient mice of both genetic backgrounds. Absence of TLR4 had no impact on NK cell recruitment or NK activity nor on recruitment of other pulmonary inflammatory cells. Activation of RSV-specific T cell immunity, including T cell mediated immunopathology, was normal in all mutant strains. These findings clearly argue against a significant role for TLR4 and define a limited role for IL-12 in primary murine RSV infection.
Similar articles
-
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.Nat Immunol. 2000 Nov;1(5):398-401. doi: 10.1038/80833. Nat Immunol. 2000. PMID: 11062499
-
Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease.J Infect Dis. 2004 Jun 1;189(11):2057-63. doi: 10.1086/420830. Epub 2004 May 12. J Infect Dis. 2004. PMID: 15143473
-
Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways.J Infect Dis. 2002 Nov 1;186(9):1199-206. doi: 10.1086/344644. Epub 2002 Oct 11. J Infect Dis. 2002. PMID: 12402188
-
Respiratory syncytial virus-induced immunoprotection and immunopathology.Viral Immunol. 2004;17(3):370-80. doi: 10.1089/vim.2004.17.370. Viral Immunol. 2004. PMID: 15357903 Review.
-
The role of Toll-like receptors in regulating the immune response against respiratory syncytial virus.Crit Rev Immunol. 2009;29(6):531-50. doi: 10.1615/critrevimmunol.v29.i6.40. Crit Rev Immunol. 2009. PMID: 20121698 Review.
Cited by
-
In Hot Pursuit of the First Vaccine Against Respiratory Syncytial Virus.Yonsei Med J. 2016 Jul;57(4):809-16. doi: 10.3349/ymj.2016.57.4.809. Yonsei Med J. 2016. PMID: 27189271 Free PMC article. Review.
-
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence.J Exp Med. 2005 Mar 21;201(6):1007-18. doi: 10.1084/jem.20041442. Epub 2005 Mar 14. J Exp Med. 2005. PMID: 15767367 Free PMC article.
-
Translational mini-review series on Toll-like receptors: recent advances in understanding the role of Toll-like receptors in anti-viral immunity.Clin Exp Immunol. 2007 Feb;147(2):217-26. doi: 10.1111/j.1365-2249.2006.03301.x. Clin Exp Immunol. 2007. PMID: 17223961 Free PMC article. Review.
-
The Anti-Apoptotic Effect of Respiratory Syncytial Virus on Human Peripheral Blood Neutrophils is Mediated by a Monocyte Derived Soluble Factor.Open Virol J. 2011;5:114-23. doi: 10.2174/1874357901105010114. Epub 2011 Oct 18. Open Virol J. 2011. PMID: 22046209 Free PMC article.
-
Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity.J Exp Med. 2008 Sep 1;205(9):2151-62. doi: 10.1084/jem.20070509. Epub 2008 Aug 25. J Exp Med. 2008. PMID: 18725520 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases